Abstract: To elucidate compositional changes of the human tissues and organs with aging, the authors investigated age-related changes of elements in the blood vessels of the arteries, veins, and thoracic duct, cardiac valves, bones of calcaneus, talus, vertebrae, auditory ossicles, and rib, cartilages of the intervertebral disk, xiphoid process, costal cartilage, pubic symphysis, and medial meniscus, ligaments of the posterior longitudinal ligament, anterior cruciate ligament, and ligamentum capitis femoris, tendons of the Achilles tendon, biceps brachii muscle, diaphragm, iliopsoas muscle, and peroneus longus muscle, nerves of the trigeminal, optic, vagus, median, radial, ulnar, femoral, sciatic, and common peroneal nerves, brains of the corpus callosum, anterior commissure, pineal body, and olfactory bulb, and organs of the prostate, uterine tube, and ureter, and reported the results.
With regard to the arteries, we found that the accumulation of Ca, P, and Mg did not occur uniformly in any arteries and that there were two types of the arteries. The first type is one that a significant accumulation of Ca and P occurs with aging, whereas the second type is one that an accumulation of Ca and P hardly occurs with aging. The thoracic and abdominal aortas, coronary, common carotid, splenic, common iliac, internal iliac, external iliac, uterine, internal pudendal, femoral, popliteal, posterior tibial, and dorsalis pedis arteries belonged to the first type, whereas the internal thoracic, cerebral, pulmonary, axillary, brachial, radial, ulnar, and obturator arteries belonged to the second type.
In addition, we found that the accumulation of Ca and P was accompanied by increase of Mg and decrease of S in most, but not all of human arteries.
In the present conference, we present mainly the compositional changes of the arteries of the coronary and uterine arteries and brains of the corpus callosum, and olfactory bulb and tract with aging.